Elisabeth I Minder Selected Research

Ferrochelatase (Heme Synthetase)

1/2020	Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria.
11/2019	Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.
1/2017	Disturbed iron metabolism in erythropoietic protoporphyria and association of GDF15 and gender with disease severity.
1/2017	Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.
10/2013	Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).
12/2010	Exacerbation of erythropoietic protoporphyria by hyperthyroidism.
4/2007	Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria.
5/2003	A "null allele" mutation is responsible for erythropoietic protoporphyria in an Israeli patient who underwent liver transplantation: relationships among biochemical, clinical, and genetic parameters.

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Elisabeth I Minder Research Topics

Disease

16	Erythropoietic Protoporphyria 01/2021 - 05/2003
7	Phototoxic Dermatitis (Phototoxicity) 11/2019 - 03/2009
7	Acute Intermittent Porphyria (Porphyria, Acute) 03/2015 - 01/2002
4	Iron Deficiencies 11/2019 - 10/2013
3	Hypochromic Anemia (Chlorosis) 11/2019 - 01/2015
2	Pain (Aches) 01/2017 - 11/2009
2	Anemia 01/2017 - 01/2017
2	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 07/2015 - 02/2010
2	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 03/2015 - 08/2006
2	Porphyrias (Porphyria) 04/2009 - 08/2006
1	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2021
1	Liver Diseases (Liver Disease) 01/2017
1	Inflammation (Inflammations) 01/2017
1	Chronic Disease (Chronic Diseases) 01/2017
1	Liver Neoplasms (Liver Cancer) 03/2015
1	Melanoma (Melanoma, Malignant) 03/2013
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2012
1	Skin Diseases (Skin Disease) 12/2010
1	Graves Disease (Basedow Disease) 12/2010
1	Rare Diseases (Rare Disease) 12/2010
1	Lichen Sclerosus et Atrophicus (Lichen Sclerosus) 08/2010
1	Erythema 11/2009
1	Edema (Dropsy) 11/2009
1	Endometrial Neoplasms (Endometrial Cancer) 03/2009
1	Pulmonary Embolism 06/2003
1	Acute Coronary Syndrome 06/2003
1	Sepsis (Septicemia) 06/2003
1	Stroke (Strokes) 06/2003
1	Coronary Artery Disease (Coronary Atherosclerosis) 06/2003
1	Critical Illness (Critically Ill) 06/2003
1	Renal Insufficiency (Renal Failure) 06/2003

Drug/Important Bio-Agent (IBA)

10	Heme (Haem)IBA 11/2019 - 03/2002
8	protoporphyrin IXIBA 01/2021 - 03/2009
8	Ferrochelatase (Heme Synthetase)IBA 01/2020 - 05/2003
6	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 03/2015 - 01/2002
5	EnzymesIBA 11/2019 - 12/2010
5	IronIBA 11/2019 - 01/2015
5	afamelanotideIBA 01/2017 - 12/2010
3	Melanocyte-Stimulating Hormones (MSH)IBA 01/2015 - 12/2010
2	Protoporphyrinogen Oxidase (Protox)IBA 03/2015 - 08/2006
2	AcidsIBA 01/2015 - 03/2009
2	AntibodiesIBA 01/2015 - 12/2010
2	Pharmaceutical PreparationsIBA 12/2010 - 04/2009
2	alpha-MSHIBA 11/2009 - 01/2009
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021
1	OligonucleotidesIBA 01/2020
1	Ferritins (Ferritin)IBA 11/2019
1	Aminolevulinic Acid (Levulan)FDA Link 11/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017
1	Type 1 Melanocortin ReceptorIBA 01/2017
1	Melanins (Melanin)IBA 01/2017
1	AntioxidantsIBA 01/2017
1	IsoenzymesIBA 01/2015
1	Proteins (Proteins, Gene)FDA Link 10/2013
1	Small Interfering RNA (siRNA)IBA 10/2013
1	DioxygenasesIBA 10/2013
1	Splicing Factor U2AFIBA 10/2013
1	Neutralizing AntibodiesIBA 03/2013
1	heme arginateIBA 01/2012
1	Charcoal (Charbon)IBA 01/2012
1	Glucose (Dextrose)FDA LinkGeneric 01/2012
1	AlbuminsIBA 01/2012
1	Iodide Peroxidase (Deiodinase)IBA 12/2010
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 12/2010
1	Thyroxine (Levothyroxine)FDA LinkGeneric 12/2010
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 12/2010
1	Thyrotropin Receptors (Thyrotropin Receptor)IBA 12/2010
1	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA 02/2010
1	Photosensitizing Agents (Photosensitizers)IBA 11/2009
1	hypericinIBA 03/2009
1	TroponinIBA 06/2003

Therapy/Procedure

2	Liver Transplantation 01/2012 - 05/2003
1	Hemodiafiltration 01/2012
1	Therapeutics 12/2010